Phage 8–10 identifies an RFLP on 11q23-qter [HGM9 no. D11S286]

Polymorphous low grade adenocarcinoma with distant metastases and deletions on chromosome 6q23-qter and 11q23-qter: a case report.

Polymorphous low grade adenocarcinomas (PLGAs) are thought to be indolent tumours that are localised preferentially to the palate and affect the minor salivary glands almost exclusively. Metastases to locoregional lymph nodes occur in only 6-10% of cases. Recently, two cases of PLGA with microscopically confirmed distant metastases have been reported. This study reports a third case of PLGA wit...

Trisomy 3p23----pter and monosomy 11q23----qter in an infant with two translocation carrier parents.

A newborn male infant with multiple congenital abnormalities was found to be trisomic for 3p23----pter and monosomic for 11q23----qter. His parents were both carriers of a balanced reciprocal translocation. Considerable overlap in phenotype-karyotype correlations was found between the two chromosomal syndromes in the patient.

RFLP identified by the anonymous DNA segment FZ IV E11 at 1p23 [HGM9 no.D1S87].

At least nine cases of trisomy 11q23-->qter in one generation as a result of familial t(11;13) translocation.

Carriers of balanced reciprocal translocations may have a (high) risk for producing liveborn children with an unbalanced karyotype. We report a large family in which a translocation between the long arm of chromosome 11 and the short arm of chromosome 13 is segregating in at least five generations. During the course of our study 15 carriers of the balanced translocation were identified and nine...

A PPY cDNA clone identifies a frequent RFLP.

SOURCE/DESCRIPTION: A pancreatic polypeptide cDNA clone (465 base pair Insert 1n the vector pBR322) was isolated from a library created from human pancreatic neoplasm RNA. This cDNA clone spans a 95 amino acid sequence in the coding region with a 29 amino add amino terminus leader sequence, a three amino acid connecting sequence and a 27 amino add carboxyl terminus (Takeuchi and Yamada, 1985). ...